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DxS' TheraScreen(R) K-RAS Companion Diagnostic Approved For Use With Amgen's Vectibix™ In Canada
DxS, a personalised medicine company, has had its TheraScreen: K-RAS Mutation Kit granted a licence by the regulatory body Health Canada for use as a diagnostic for anti-EGFR therapies and as the companion diagnostic for Amgen"s colorectal cancer therapy, Vectibix™ (panitumumab).
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Drive For Good Quality Medicines, Foods Reinforced By USP Agreements With Chinese Drug Authorities
As part of its efforts to improve the quality of medicines and food ingredients worldwide, the U.S. Pharmacopeial (USP) Convention this week reached three new cooperative agreements with Chinese drug control authorities. Because Chinese manufacturers supply so much of the world"s drug and food ingredients, these agreements-coupled with three previous agreements between USP and other government organizations in China-mark a significant commitment to ensure that concerns about quality are addressed. USP is a scientific, nonprofit organization that sets standards for the quality of prescription and over-the-counter drugs that are enforced by the U.S. Food and Drug Administration (FDA) in the United States. USP also sets standards for the quality of food ingredients and dietary supplements; these and USP"s drug standards are used in more than 130 countries.
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Boston To Unveil New Teen Sex Awareness Program After Spike In STI Cases
Boston"s health agency on Tuesday is scheduled to launch a safer-sex campaign that reaches out to teenagers through Web sites such as Facebook and YouTube, the Boston Globe reports. The campaign was created in response to rising rates of sexually transmitted infections among young people in the city, according to the Globe. The $100,000 campaign originally was intended to address communicable diseases in general. However, experts noticed the increase in STI cases among teenagers and decided to spend all the funding on the campaign targeting STIs.The increase in chlamydia cases in particular demonstrates the "scope of the challenge," as 1,383 Boston youths between ages 15 and 19 were diagnosed with the STI in 2007, a 70% increase since 1999, the Globe reports. The overall rate of chlamydia in Boston is more than twice the national average, and chlamydia and gonorrhea are more common among adolescents than any other age group in Boston. According to the Globe, a city study released in early 2009 found that 56% of Boston public high school students have had sex, and 24% of the sexually active students said they have had more than six partners.For the campaign, "teenagers will do much of the talking" in a video that offers information on STIs, the Globe reports. The video will air on cable channels that are popular with teenagers, such as MTV, FX and BET. It shows teenagers in a classroom receiving information on safer sex, including details about condoms and STI screening. The video does not discuss sexual abstinence.The campaign also includes advertisements on mass transit and the radio, as well as a team of teenagers that will travel around Boston performing street theater addressing the risks associated with STIs. Through the social networking Web site Facebook, teenagers can post questions anonymously regarding sexual health that will be answered by a disease specialist. Videos related to the campaign also will be posted on YouTube.Margaux Joffe, multimedia coordinator at the Public Health Commission, said teenagers "told us, "We don"t want some 40-year-old woman telling us about sex and STIs."" Joffe added that it "makes sense" because a teenager "may not trust the advice of an adult as much as you would someone in your peer group." Mark Schuster, the chief of general pediatrics at Children"s Hospital Boston who was not involved in the design of the campaign, said that using a "multilevel approach" to address the issue is a "great strategy." He added that young people "can be interested and learn from" a sex education curriculum in school, but "they need it in other settings too."Specialists speculate that the rise in STIs may reflect teenagers" casual attitudes about sex and parents" shifting attention to other children"s health concerns, the Globe reports. Experts also have said that the increase in STIs could reflect increased screening efforts by physicians, who have been "pressed for many years to screen much more carefully kids at younger and younger ages," Stephen Boswell, president of Fenway Health, said. The Globe reports that teenagers do not view HIV/AIDS in the same way previous generations have because of advancements in treatment, so preventing the virus "no longer seems quite as important." Experts are concerned that the spread of other STIs could be a forewarning of a rise in HIV/AIDS cases among teenagers. Anita Barry, a top disease specialist at BPHC, said the gonorrhea and chlamydia cases are "our future HIV cases unless we intervene" (Smith, Boston Globe, 8/4).
Cardiovascular

A Silly Pat On The Head Helps Seniors Remember Daily Med

Doing something unusual, like knocking on wood or patting yourself on the head, while taking a daily dose of medicine may be an effective strategy to help seniors remember whether they"ve already taken their daily medications, suggests new research from Washington University in St. Louis. We"ve all heard warnings that some medications may be habit-forming, but research also shows that "getting into the habit" of taking a daily medicine in a routine and precise fashion can be a befuddling challenge for some older adults, many of whom tend to err on the side of over-medication, taking a dangerous second dose when in doubt about the first. "In extended medication-taking situations, the habitual nature of the task may make it difficult for older adults to remember whether or not they took the medication on a particular day, especially if pill boxes are not used," explains Mark McDaniel, Ph.D., lead author of the study and a professor of psychology in Arts & Sciences at Washington University. "To remedy this potential problem, older adults could be instructed to take their medication while placing one hand on their head or in some other unusual or silly way, like crossing their arms," he suggests. "Our results indicate that older adults can use these sorts of more complex motor tasks to effectively reduce repetition errors in habitual prospective memory tasks, such as taking a daily medication." The study, published in a recent issue of the journal Aging, Neuropsychology, and Cognition, is co-authored by Julie M. Bugg, Ph.D., postdoctoral research scholar in psychology at Washington University; Grit M. Ramuschkat of the Department of Psychology at the University of Heidelberg, Germany; Matthias Kliegel of the Department of Psychology, Technische Universitç¤t Dresden, Germany; and Giles O. Einstein, professor and chair of psychology at Furman University in South Carolina. McDaniel and Einstein co-authored a 2004 book on "Memory Fitness: A Guide for Successful Aging" and a 2007 book on the latest research into the nuances of prospective memory, the process of remembering to perform an action at an appropriate time in the future. In previous research, they"ve shown that older adults are more likely to incorrectly repeat an action in situations where a prospective memory task has become routine or habitual in nature. Extending that line of research, the current study examines whether the tendency of older adults to err on the side of repeating a poorly remembered habitual task could be reduced by providing advance instructions to omit doing a task if in doubt about whether it was previously executed. The study also tested whether doing something unusual while executing a task would help seniors remember having done the task. Specifically, participants were asked to push the F1 key on a computer keyboard once and only once at some point at least 30 seconds into a series of relatively simple, three-minute-long, letter-recognition tasks, such as pushing the computer key for the letter that comes next in the alphabet after a letter being displayed on the monitor (see a "g" and push an "h"). One subset of the older study participants was instructed to put a hand on their heads whenever they pushed the F1 key. In another phase of the experiment, participants were asked to do the letter-recognition task while simultaneously carrying out an additional more complicated and distracting task listening to a series of random numbers and pushing a clicker whenever they heard two odd numbers in a row. The performance of older adults averaging 72 years of age was compared with results from a group of college students put through the same trials. "When ongoing task demands were challenging, older adults committed more repetition errors than younger adults, regardless of whether they"d been told in advance to err on the side of omission told not to push the F1 key if they had any doubt about whether it had already been pushed once in the same trial," says McDaniel. However, older adults asked to carry out the more complex motor task (placing hand on head) while pushing the F1 key made significantly less repetition errors than older adults not making use of this memory enhancing technique. And, in situations where the ongoing tasks were not overly complicated and distracting, older adults using this memory technique were able to reduce their repetition errors to levels comparable with those of younger adults. This finding, along with other data from the study, suggests that older participants can learn to monitor their output and make better mental notes regarding the completion of a prospective memory task. "For applied purposes, using a distinct motor activity to minimize repetition errors in older adults" prospective memory tasks would seem to have great potential. In light of these findings, it seems reasonable to conclude that, at least in a context in which the ongoing activity is not overly demanding, older adults can implement strategies that are effective for supporting execution and output monitoring of habitual prospective memory tasks," McDaniel concludes. Washington University in St. Louis


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