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SAMe Is Effective In Preventing Formation Of Primary Liver Cancer In Rats
A new study investigated the effectiveness of S-adenosylmethionine (SAMe) in the prevention and treatment of hepatocellular carcinoma (HCC) or primary liver cancer. SAMe, a widely available nutritional supplement, with little known side effects, was found to be effective in preventing the formation of HCC in rats. However, high enough levels of SAMe were not attainable to successfully treat established HCC. The findings are available in the August issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases.
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Ben-Gurion U. Researchers Identify How Stressed Fat Tissue Malfunctions
Ben-Gurion University of the Negev (BGU) researchers, in a collaboration with colleagues from the University of Leipzig, Germany, have identified a signaling pathway that is operational in intra-abdominal fat, the fat depot that is most strongly tied to obesity-related morbidity.
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Experts Urge Increased Education About Diabetes During Pregnancy
The American College of Obstetricians and Gynecologists and the American Diabetes Association next month plan to launch a joint campaign designed to raise awareness about pregnancy-related risks from diabetes, USA Today reports. An increasing number of women are either beginning pregnancies with existing Type 1 or Type 2 diabetes -- known as pre-gestational diabetes -- or developing gestational diabetes, according to Sue Kirkman, vice president of clinical affairs for ADA. Kirkman said that diabetes increases the risk for miscarriage, delivery complications, maternal health problems and birth defects. However, these risks can be reduced through preconception counseling, controlling blood sugar and maintaining a healthy weight, she said. According to the Centers for Disease Control and Prevention, almost five of every 1,000 women ages 18 to 44 have diabetes. The majority of these women have Type 2 diabetes, which is linked to obesity, USA Today reports. Denise Charron-Prochownik, an associate professor of health promotion at the University of Pittsburgh Medical Center School of Nursing and Graduate School of Public Health, said that pre-conception education for women with existing diabetes should begin as early as age 13 but that "it"s not happening."Helain Landy, chair of the Department of Obstetrics and Gynecology at Georgetown University Hospital, said that gestational diabetes occurs in about 4% of pregnant women. Landy said, "From an epidemiological standpoint, that is a lot." Florence Brown, co-director of the Joslin Beth Israel Deaconess Medical Center"s Diabetes and Pregnancy Program, said that many women with gestational diabetes are unaware that they are more likely to develop cardiovascular disease later in life and have children who develop diabetes (Brophy Marcus, USA Today, 7/6).
Diagnostics

AICR Statement: Hot Dogs And Cancer Risk

The American Institute for Cancer Research (AICR) and our landmark 2007 AICR/WCRF expert report, Food, Nutrition, Physical Activity and the Prevention of Cancer: a Global Perspective, have been drawn into a controversy over the link between processed meat and cancer risk. A class-action consumer-fraud lawsuit was filed on July 22 against various manufacturers of hot dogs for failing to warn consumers that consumption of hot dogs increases cancer risk. The lawsuit cites evidence from our expert report showing that processed meat consumption is associated with an increased risk of colon cancer. What You Should Know: - Based on the conclusions of our 2007 expert report, AICR recommends limiting consumption of red meat to 18 ounces (cooked) per week, and avoiding processed meat. This is just one of the 10 AICR recommendations for cancer prevention. - AICR does not take a position on the need for warning labels on hot dogs. - AICR is an independent, research-based organization. We fund research on diet and cancer at laboratories, clinics and cancer centers across the country. We also periodically collect and interpret the available data on diet and cancer and issue recommendations for cancer prevention. - AICR is not associated with the Cancer Project, the Physicians Committee for Responsible Medicine or any other advocacy organization. - Our 2007 expert report compiled and analyzed over 7000 studies on all aspects of diet, physical activity, body weight and cancer. - The AICR/WCRF expert panel weighed the evidence on all potential associations and concluded that the link between diets high in red and processed meat and colorectal cancer is convincing. - On the subject of processed meat (hot dogs, cold cuts, ham, etc.) and colon cancer, the collected evidence indicates that every 50 gram serving of processed meat (roughly equivalent to 1 hot dog) eaten per day increases colorectal cancer risk by 21 percent. (Note: this means that people who eat a hot dog every day have a 21 percent higher risk of colorectal cancer than if they never eat hot dogs.) - A 21 percent higher risk is significant and cause for concern; that is why our recommendation is to avoid processed meat. - But, to put that increased risk in context: A regular smoker has a risk of lung cancer that is between 10 and 20 times that of a nonsmoker. In contrast, a person who eats one hot dog every day has a 21 percent higher risk of colorectal cancer - not even two times the risk of someone who never eats hot dogs. - In our literature, AICR does not call on individuals to ban all processed meat from the diet completely. But the evidence does indicate that it makes sense to avoid processed meat when possible. - The AICR/WCRF expert report is a living document. We are continually updating the report"s database with new evidence from emerging studies. An expert panel periodically reviews these new data and determines whether any of AICR"s 10 recommendations need to be changed. - We anticipate that the review of all relevant evidence on colorectal cancer that has appeared since the expert report"s 2007 publication will be completed by the end of this year. At that time, the expert panel will determine whether the recommendation on red and processed meet needs to be changed. - Representatives of the meat industry have attacked our recommendation, citing their own privately commissioned, unpublished meta-analysis. We have reviewed and responded to these criticisms elsewhere. The expert panel stands by its judgment of the evidence, and AICR stands by the report"s transparent, peer-reviewed, comprehensive methodology. The take home message: More people need to know about the healthy everyday choices that can lower risk for cancer. About 1/3 of the most common cancers could be avoided simply by eating a healthy diet, moving more and staying lean. We at AICR work every day to help people make healthy choices; we are committed to changing lives to save lives. American Institute for Cancer Research


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