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New Research At University Of Leicester Offers Hope For Heart And Cancer Treatments
Researchers in the Department of Cardiovascular Sciences at the University of Leicester are developing a new way to make protein based drugs with potential applications in stroke, vascular inflammation, blood vessel formation, regenerative medicine and tissue engineering.
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Caffeic Acid Inhibits Colitis In A Mouse Model
Researchers at Iowa State University have found that increased expression of a form of cytochrome P-450 (CYP4B1) is a key marker of inhibition of colitis in mice by caffeic acid, an anti-inflammatory antioxidant compound widely distributed in foods. The results, which appear in the June 2009 issue of Experimental Biology and Medicine, implicate CYP4B1, a form of cytochrome P450 previously found to be associated with resolution of allergic inflammation in another model. The normalization of CYP4B1 by caffeic acid treatment was associated with significant lessening of colitic damage, assessed by examining colon histopathology. In comparison with rutin, an anti-inflammatory flavonoid and hypoxoside extract, a botanical known as African potato previously shown to protect against colitis, all three compounds had anti-inflammatory effects, suppressing myeloperoxidase, IL-17 and iNOS and increasing IL-4, known factors associated with inflammation responses. But only caffeic acid protected against the dextran sulfate sodium induced colitis. Its novel mechanism related to CYP4B1 is being studied further. The research team, Zhong Ye, a graduate student in Toxicology, along with Microbiology graduate students Zhiping Liu and Abigail Henderson, Visiting Scientist Kwangwon Lee, Korea University, Dr. Michael Wannemuehler, Veterinary Microbiology, Dr. Jesse Hostetter, a veterinary pathologist, and Dr. Suzanne Hendrich, Toxicologist and Nutritionist, performed studies in 8 week old mice fed the various dietary components and then exposed to dextran sulfate sodium in a mildly irritating dose to induce colitis. Dr. Hendrich noted that "this study of caffeic acid will help us to advance studies of botanicals and plant foods with respect to their ability and mechanisms of inhibiting colitis, and perhaps colon cancer, because colitis increases risk for this disease".
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Abbott Announces New EAS(R) Myoplex(R) Strength Formula Nutrition Shake And Debuts Bottle Packaging
Abbott announced the EAS® Myoplex® Strength Formula nutrition shake designed to help active people on the go refuel after physical activity. The ready-to-drink sports nutrition shakes come in a new, reclosable 14 fluid ounce plastic bottle.
Cardiovascular

Angina: Risk Of Heart Attack And Death Doubles In Men

A study just published on bmj.com reports that the risk of heart attack is multiplied by two for men who have angina. Also their risk of suffering a heart disease-related death is three times higher than for women with the same condition. It is the first study to associate primary and secondary care data with mortality records in order to evaluate the risks of angina among men and women. Angina is widespread in the United Kingdom and frequently it is the initial manifestation of ischaemic heart disease. The latest evaluations indicate that 4.8 percent of men and 3.4 percent of women aged over 16 in England have the condition. In Scotland angina is reported to occur in 6.6 percent of men and 5.6 percent of women. For that reason it is essential for both patients and their clinicians to comprehend the risks following a diagnosis of angina. Dr Brian Buckley of the National University of Ireland, Galway, and a team of researchers identified 1,785 patients from 40 primary care practices in Scotland. Their average age was 62 years and they were all newly diagnosed with angina between January 1998 and December 2001. Cardiovascular risk factors, such as smoking and obesity, were assessed. Also, underlying conditions, such as diabetes and high blood pressure, were recorded. In addition, the postcode of each patient was used to assign a deprivation status. For a period of five years all the participants were monitored. Research showed that being male, older and a smoker was linked with an increased risk of having a heart attack. Also, being male, older, obese and a smoker were all connected with an increased risk of death from heart disease or any cause. The probability of undergoing a procedure to open up blocked arteries, known as angioplasty (PTCA) or coronary artery bypass surgery (CABG) was also higher in men than in women. Noteworthy information was that neither procedure was linked with significant improvement in survival. The authors explain: "This study has shown that a number of characteristics, including male sex, age, smoking and obesity, in people with a first diagnosis of angina are strongly associated with subsequent risk of a number of cardiac outcomes." They conclude that these findings suggest suitable managing of risk factors and proper application of preventive medical treatments should be seriously followed for patients with angina. "Five year prognosis in patients with angina identified in primary care: incident cohort study" Brian S Buckley, Cochrane research fellow, Colin R Simpson, research fellow, David J McLernon, research fellow, AndrewWMurphy, professor of general practice, Philip C Hannaford, NHS Grampian chair of primary care and head of division of applied health sciences. BMJ 2009; 339:b3058 BMJ Written by Stephanie Brunner (B.A.)


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