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News From The Journals Of The American Society For Microbiology
Preventative Treatment Against Malaria May be Less Effective in Malnourished Children
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ABRAXANE Approved For Advanced Breast Cancer Patient Treatment In Quebec
Abraxis BioScience, Inc. (NASDAQ:ABII), an integrated biotechnology company, announced the listing of ABRAXANE® for Injectable Suspension (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) 100 mg in Quebec for the treatment of metastatic breast cancer with a recommendation from the Quebec Conseil du Mç©dicament and approval from the Quebec Ministry of Health. ABRAXANE is approved and commercially available in Canada for the treatment of metastatic breast cancer, including first-line disease. The listing of ABRAXANE in Quebec offers an important new treatment option to Quebec women with advanced breast cancer.
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Massive Medicaid Fraud Exposed: PsychRights Calls On Members Of Congress For Assistance
In letters to Senators Charles Grassley and Herb Kohl, and Representatives Henry Waxman, Bart Stupak , John Dingell & Barney Frank, the Law Project for Psychiatric Rights (PsychRights) has exposed massive Medicaid Fraud. While working on PsychRights v. Alaska , its lawsuit to prohibit the State of Alaska from the largely ineffective and always harmful psychiatric drugging of children and youth, PsychRights "discovered that it is illegal for the vast bulk of these prescriptions to be reimbursed by Medicaid."
Oncology

Can Tribble 3 Can Induce Non-Alcoholic Fatty Liver Disease?

Three pseudo kinases of the Tribbles family have been recently recognized, which include TRB1, TRB2 and TRB3. Recent research has found that the expression of hepatic TRB3 increased in a rat model of diabetes. TRB3 could block the insulin signaling pathway through inhibiting Akt activation, which contributes to insulin resistance. This research, lead by Dr. Yu-Gang Wang and his colleagues in the Department of Gastroenterology, Shanghai Changning Central Hospital, China, used real-time fluorescent quantitative reverse transcription-polymerase chain reaction technology and Western blotting analysis to study the protein expression of TRB3mRNA, Akt and phosphorylation protein kinase B during the progression of NAFLD. The expression level of TRB3mRNA in NAFLD rats was significantly higher than in normal controls. Also, the expression levels of Akt and p-Akt-Thr308 in NAFLD rats was significantly lower than the control group. Since TRB3 can block insulin signaling pathway through inhibiting Akt activation, which contributes to insulin resistance, it may be an important factor in the occurrence and development of NAFLD. This study provides an experimental basis for future studies on the role of TRB3 in NAFLD. The control of the expression level of TRB3 in liver may become a new target for NAFLD therapy. Reference: Wang YG, Shi M, Wang T, Shi T, Wei J, Wang N, Chen XM. Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease. World J Gastroenterol 2009; 15(19): 2329-2335 Correspondence to: Dr. Xi-Mei Chen, Department of Gastroenterology, Tongji Hospital of Tongji University, Shanghai 200065, China. Jian-Xia Cheng World Journal of Gastroenterology


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