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Less Invasive CT-Scan Based Colorectal Cancer Screening Method Shows Good Accuracy
Computed tomographic (CT) colonography may offer patients at increased risk of colorectal cancer an alternative to colonoscopy that is less-invasive, is better-tolerated and has good diagnostic accuracy, according to a study in the June 17 issue of JAMA.
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NEJM Perspective Provides Overview Of Recent Health Reform Action
"Building Momentum as Democrats Forge Health Care Reform," New England Journal of Medicine: In a perspective piece, John Iglehart, a national correspondent for NEJM, reviews recent action on health reform. He discusses industry and provider groups" pledge to reduce spending by $2 trillion over the next 10 years, noting that the groups" pledge was a "recognition that the pace of reform is quickening and they wanted to be a full participant in negotiations." He also addresses congressional action, including discussions of a public insurance option and how lawmakers are attempting to address the cost of reform (Iglehart, NEJM, 5/14).
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Common Antibiotics May Be Best First Treatment For Children With MRSA-related Infections
Penicillin and other antibiotics in the beta-lactam family work as well as other antibiotics to treat MRSA (methicillin-resistant Staphylococcuss aureus) infections in the skin and soft-tissue of children and may help prevent further resistance to antibiotic treatment, according to a new study funded by the Agency for Healthcare Research and Quality.
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Genomas Presents Drug-Specific Genetic Determinants Of Statin Safety And Efficacy At The XV International Symposium On Atherosclerosis

Genomas, a biomedical company advancing DNA-guided medicine and personalized healthcare, announced its participation at the prestigious XV International Symposium on Atherosclerosis, a meeting held triennially by the International Atherosclerosis Society. Gualberto Ruano, MD, PhD, President of Genomas, will present "Physiogenomic Contours of Statin Safety and Efficacy," a clinical study examining the differences in response to statin drugs based on individual gene variations. Statins offer effective strategies to reduce cardiovascular disease and improve survival. However, there are clinically relevant safety risks for some patients. Statin-induced neuro-myopathy (SINM) may present as muscle aches, cramps, weakness, and muscle injury. SINM is more frequent at the higher doses required for treating advanced heart disease, and varies in extent between individual statins and from patient to patient. In previously published studies, over 10% of statin patients experienced neuromuscular side effects, causing disruptions in daily life activities, and reduction in regimen adherence. In this study, 442 outpatients treated with atorvastatin, rosuvastatin and/or simvastatin were studied in lipid clinics at Hartford Hospital (Hartford, CT) and the University of California, San Francisco. Researchers genotyped 384 SNPs (single nucleotide polymorphisms) from 222 cardiometabolic and neuroendocrine genes with a potential role in determining the safety and efficacy of statins. The study was funded in part by a grant from the National Institute of General Medical Sciences of the National Institutes of Health. "Contrasting quantitatively how the gene polymorphisms associate with clinical responses, we visualize the "physiogenomic contours" of statin drugs," said Dr. Ruano. "These contours represent the mechanistic differences among statins, which we plan to use as the foundation for DNA-guided rules for treatment on a patient-individualized basis." ABOUT GENOMAS Genomas is a biomedical company advancing DNA-guided medicine and personalized healthcare. The company is developing and testing revolutionary PhyzioType(TM) Systems for DNA-guided diagnosis and prevention of metabolic disorders induced by drugs used to treat diabetes, and cardiovascular and psychiatric illnesses. PhyzioType Systems are designed to provide physicians with an unprecedented capability to select for each patient the safest drug treatment to enhance compliance. Genomas is located in Hartford, CT on the campus of Hartford Hospital. Genomas


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