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Latest Replikins Data Predicts Continued High Level Of H1N1 (Swine Flu) Infectivity And Lethality
Biotech firm Replikins Ltd. released its analysis of the June and July genomic data that predicts the rates of infectivity and lethality of the H1N1 (Swine Flu) virus. The quantitative analysis shows continued elevated levels in the Replikin Counts* of both Infectivity and Lethality genes, which indicate that the end of the current outbreak is not yet in sight.
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CEL-SCI Developing Immune-Based Treatment Against Swine And Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology
CEL-SCI Corporation (NYSE AMEX: CVM) announced that it is developing an immune-based treatment for the "swine flu and related H1N1" flu viruses, utilizing its proprietary L.E.A.P.S.(TM) (Ligand Epitope Antigen Presentation System) vaccine technology. The Company plans to utilize the expertise and knowledge it has gained from developing protective and therapeutic vaccines utilizing L.E.A.P.S. to develop a therapeutic treatment based upon the technology for people infected with the swine and H1N1 flu viruses. CEL-SCI has already commenced pre-clinical testing.
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St. Joseph's Selected As Only Site To Provide New Genetic Test For Deadly Type Of Brain Cancer
St. Joseph"s Hospital and Medical Center in Phoenix has partnered with Castle Biosciences, Inc. to provide the nation"s first genomics-based test for patients suffering from glioblastoma multiforme, the most deadly form of primary brain cancer. This new test is used to help doctors and patients consider various treatment options.
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Microproteinuria: Indicator To Monitor CNI-Related Nephrotoxicity In Liver Transplant Recipients?

Deterioration of renal function with CNI therapy has been widely reported in liver transplant recipients. Microproteinuria has been used to monitor the early changes of nephropathy in renal disease or cardiovascular events. However, whether microproteinuria could be used as an early and sensitive indicator to monitor CNI-related nephrotoxicity in liver transplant recipients has not been unequivocally addressed. A research article published in the World Journal of Gastroenterology addresses this question. The research team led by Professor Yan from West China Hospital of Sichuan University studied the use of microproteinuria in early diagnosis of CNI-related nephrotoxicity after liver transplantation. Measurements of microproteinuria including 1-microglobulin (1m), 2-microglobulin (2m), immunoglobulin, microalbumin and transferrin were performed with a Dade Behring array nephelometry system. Follow-up data of this study demonstrated that there was a downward trend in renal function over time, with the persistence of microproteinuria. The urinary concentration of 2m and 1m significantly increased with the subtle changes in renal function in the study groups, but the levels of SCr and BUN significantly increased only when renal function was severely damaged by CNI nephrotoxicity. The subsequent reductions in GFR were closely correlated with the increases in ΁1m and 2m. Fewer patients were found to have 2m in the urine than 1m in this study as 2m is unstable in fresh urine. This problem can partly be overcome by maintaining the urine pH value (by adding basic buffer to the urine) to prevent the degradation of 2m. This study suggested that urinary 2m and ΁1m are sensitive urinary markers for detecting CNI-related nephrotoxicity in liver transplant recipients. The results are interesting and may represent a screening method to prevent the progression of CNI-related subclinical renal dysfunction after liver transplantation. Reference: Li J, Liu B, Yan LN, Wang LL, Lau WY, Li B, Wang WT, Xu Q, Yang JY, Li FG. Microproteinuria for detecting calcineurin nhibitor-related nephrotoxicity after liver transplantation. World J Gastroenterol 2009; 15(23): 2913-2917 http://www.wjgnet.com/1007-9327/15/2913.asp Correspondence to: Lu-Nan Yan, Division of Liver ransplantation, West China Hospital, Sichuan University, hengdu 610041, China. Lin Tian World Journal of Gastroenterology


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