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Scientists Uncover Patterns Of Genetic Changes In Mental Retardation
Researchers at Radboud University Medical Centre, together with UK
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Caffeic Acid Inhibits Colitis In A Mouse Model
Researchers at Iowa State University have found that increased expression of a form of cytochrome P-450 (CYP4B1) is a key marker of inhibition of colitis in mice by caffeic acid, an anti-inflammatory antioxidant compound widely distributed in foods. The results, which appear in the June 2009 issue of Experimental Biology and Medicine, implicate CYP4B1, a form of cytochrome P450 previously found to be associated with resolution of allergic inflammation in another model. The normalization of CYP4B1 by caffeic acid treatment was associated with significant lessening of colitic damage, assessed by examining colon histopathology. In comparison with rutin, an anti-inflammatory flavonoid and hypoxoside extract, a botanical known as African potato previously shown to protect against colitis, all three compounds had anti-inflammatory effects, suppressing myeloperoxidase, IL-17 and iNOS and increasing IL-4, known factors associated with inflammation responses. But only caffeic acid protected against the dextran sulfate sodium induced colitis. Its novel mechanism related to CYP4B1 is being studied further. The research team, Zhong Ye, a graduate student in Toxicology, along with Microbiology graduate students Zhiping Liu and Abigail Henderson, Visiting Scientist Kwangwon Lee, Korea University, Dr. Michael Wannemuehler, Veterinary Microbiology, Dr. Jesse Hostetter, a veterinary pathologist, and Dr. Suzanne Hendrich, Toxicologist and Nutritionist, performed studies in 8 week old mice fed the various dietary components and then exposed to dextran sulfate sodium in a mildly irritating dose to induce colitis. Dr. Hendrich noted that "this study of caffeic acid will help us to advance studies of botanicals and plant foods with respect to their ability and mechanisms of inhibiting colitis, and perhaps colon cancer, because colitis increases risk for this disease".
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New Research At University Of Leicester Offers Hope For Heart And Cancer Treatments
Researchers in the Department of Cardiovascular Sciences at the University of Leicester are developing a new way to make protein based drugs with potential applications in stroke, vascular inflammation, blood vessel formation, regenerative medicine and tissue engineering.
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Minorities, Poor Find Communicating With Doctors More Difficult

Patient-provider communication influences quality of care, but black and Asian patients were more likely than white patients to report communication difficulties with their doctors in 2005, according to the latest News and Numbers from the Agency for Healthcare Research and Quality. Good communication is important for the medical care provider to understand the patient"s needs, wants, and preferences, and for the patient to understand and participate in his or her own care. AHRQ found that roughly 13 percent of blacks and Asians reported communication problems with their doctors in 2005, compared with 9 percent of whites. Moreover, the gap between blacks and whites widened between 2002 and 2005. In contrast, the gap between Hispanic and non-Hispanic white adults narrowed . Even so, about 12 percent of Hispanic adults reported difficulties communicating with their doctors in 2005. The federal agency"s analysis also showed that: - Roughly twice as many poor people as high-income people, regardless of their race or ethnicity, reported communication problems in 2005 (15 percent vs. 7 percent). - Among high school graduates, blacks (13 percent) were more likely that whites (9 percent), and Hispanics (12 percent) were more likely than whites (8.5 percent) to report poor communication with their health providers. - Among people with less than a high school education, blacks were more likely than whites to report communication problems (18.6 percent and 12.5 percent respectively). This AHRQ News and Numbers summary is based on data from the 2008 National Healthcare Disparities Report , which examines the disparities in Americans" access to and quality of health care, with breakdowns by race, ethnicity, income, and education. Agency for Healthcare Research and Quality


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