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Serum Bile Acid Profiling For Inflammatory Bowel Disease Characterization
Based on serum bank material, BA profiling was applied in IBD patients and healthy controls which showed that most but not all BA species were decreased to a different extent in CD and UC. BA decreases were highly pronounced in CD patients with surgical interventions in the gut. On the other hand, UC patients with additional liver and gallbladder diseases showed clearly increased levels of those BAs that are synthesized directly in the liver (primary BAs), or subsequently modified by intestinal bacteria (secondary BAs). Furthermore, a marked decrease in the toxic BA lithocholic acid (LCA) was found together with a marked increase in its physiological detoxification product, hyodeoxycholic acid (HDCA), irrespective of the IBD phenotype or clinical manifestation, which showed accelerated detoxification activity in IBD patients. Thus, serum BA profiling might serve as an additional diagnostic tool for IBD characterization and differentiation. In combination with expression profiles of nuclear pregnane X receptor (PXR)-regulated genes, it might allow us to estimate the BA detoxification potential of IBD patients.
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Report Calls Tennessee's Barebones Health Plan A Bad Model For Other States To Follow
A first-of-its-kind report released today by the national consumer health organization Families USA analyzes the Tennessee health care plan CoverTN, spotlights numerous problems with the plan, and calls CoverTN a bad model for other states to follow as they seek to assist their own uninsured residents.
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Heart Electrical Conduction Abnormality Believed Not To Be Serious May Pose Cardiovascular Risks
New research indicates that a finding on a routine electrocardiogram that signals a disorder of the electrical conducting system in one part of the heart and previously believed to be benign is associated with an increased risk for atrial fibrillation, the implantation of a pacemaker or death, according to a study in the June 24 issue of JAMA.
Oncology

Minorities, Poor Find Communicating With Doctors More Difficult

Patient-provider communication influences quality of care, but black and Asian patients were more likely than white patients to report communication difficulties with their doctors in 2005, according to the latest News and Numbers from the Agency for Healthcare Research and Quality. Good communication is important for the medical care provider to understand the patient"s needs, wants, and preferences, and for the patient to understand and participate in his or her own care. AHRQ found that roughly 13 percent of blacks and Asians reported communication problems with their doctors in 2005, compared with 9 percent of whites. Moreover, the gap between blacks and whites widened between 2002 and 2005. In contrast, the gap between Hispanic and non-Hispanic white adults narrowed . Even so, about 12 percent of Hispanic adults reported difficulties communicating with their doctors in 2005. The federal agency"s analysis also showed that: - Roughly twice as many poor people as high-income people, regardless of their race or ethnicity, reported communication problems in 2005 (15 percent vs. 7 percent). - Among high school graduates, blacks (13 percent) were more likely that whites (9 percent), and Hispanics (12 percent) were more likely than whites (8.5 percent) to report poor communication with their health providers. - Among people with less than a high school education, blacks were more likely than whites to report communication problems (18.6 percent and 12.5 percent respectively). This AHRQ News and Numbers summary is based on data from the 2008 National Healthcare Disparities Report , which examines the disparities in Americans" access to and quality of health care, with breakdowns by race, ethnicity, income, and education. Agency for Healthcare Research and Quality


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