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Fish Protein Link To Controlling High Blood Pressure, New Study
Medical scientists at the University of Leicester are investigating how a species of fish from the Pacific Ocean could help provide answers to tackling chronic conditions such as hereditary high blood pressure and kidney disease.
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Schizophrenia: A Genetic Basis
Schizophrenia is a severely debilitating psychiatric disease that is thought to have its roots in the development of the nervous system; however, major breakthroughs linking its genetics to diagnosis, prognosis and treatment are still unrealized. Jill Morris, PhD assistant professor of Pediatrics at Northwestern University"s Feinberg School of Medicine and a researcher in the Human Molecular Genetics Program of Children"s Memorial Research Center studies a gene that is involved in susceptibility to schizophrenia, Disc1 (Disrupted-In-Schizophrenia 1). Two recent publications by Morris and colleagues focus on the role of Disc1 in development, particularly the migration of cells to their proper location in the brain and subsequent differentiation into their intended fate. During development, cells need to properly migrate to their final destination in order to develop into the appropriate cell-type, integrate into the corresponding network of cells and function properly. Disruption of cell migration can lead to inappropriate cell development and function, resulting in disease.
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New Rapid 4th Generation Point Of Care HIV Test Identifies Acute Infection Earlier Than Antibody Only Tests
The new 4th generation rapid HIV diagnostic test - Determine® HIV 1/2 Ag/Ab Combo - from Inverness Medical is capable of detecting HIV infection several days earlier than HIV antibody only tests and is ideal to help diagnose and screen for early HIV infection. The ability of this test to enhance the diagnosis of those with acute HIV infection will provide additional benefits in HIV prevention programs and ultimately contribute to a reduction in the spread of HIV. Inverness Medical will be showcasing the new Determine Combo test at the International AIDS Society Conference 2009 in Capetown, South Africa, 19-22 July on stand #203.
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Nephrogenic Systemic Fibrosis And Gadolinium-Based Contrast Agents

Even at very high doses, gadolinium-based contrast agents alone are not sufficient to cause nephrogenic systemic fibrosis (NSF) in patients with kidney problems, according to a study performed at the Mayo Clinic Florida, Jacksonville, FL. NSF is a rare and serious syndrome that leads to fibrosis of the skin, joints and even internal organs. Some research indicates NSF is caused by gadolinium-based contrast agents that are commonly used today during MR procedures. The study examined the records of 61 patients. "Our patients had been given high doses - from two to ten times the usual MRI dose. These high doses were used because the patients were undergoing interventional procedures and the procedures were done before there were any reports linking gadolinium to NSF," said Mellena D. Bridges, MD, lead author of the study. "Fortunately, one of these patients, a 58-year-old diabetic man with end-stage kidney disease and significant blood vessel blockages, developed NSF. Gadolinium seems to be necessary to trigger NSF, but it doesn"t seem to be enough to cause the disease, even at very high doses," said Dr. Bridges. This study appears in the June issue of the American Journal of Roentgenology. Click here for abstract. Heather Curry American Roentgen Ray Society


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