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Nexavar® In Combination With Chemotherapy Shown To Extend Progression-Free Survival In Patients With Advanced Breast Cancer
Bayer HealthCare AG and Onyx Pharmaceuticals, Inc. announced that their first cooperative group-sponsored randomized Phase II trial in advanced metastatic breast cancer met its primary endpoint of progression-free survival. The study evaluated Nexavar® (sorafenib) tablets in combination with the oral chemotherapeutic, capecitabine, in patients with locally advanced or metastatic HER-2 negative breast cancer. Study findings demonstrated that the median progression-free survival was extended in patients treated with Nexavar and capecitabine compared to patients receiving capecitabine and placebo. These results were statistically significant (p-value = 0.0006). In this trial, the safety and tolerability of the combination was as expected and did not show any new or unexpected toxicities. A complete data analysis from this study is expected to be presented at an upcoming scientific meeting.
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South African AIDS Advocate Who Created Radio Diaries Dies Of Drug-Resistant TB
South African AIDS activist Thembi Ngubane recently died of drug-resistant tuberculosis at the age of 24, the AP/Washington Post reports (Nullis, AP/Washington Post, 6/14). According to the Wall Street Journal, "millions of radio listeners around the world" heard Ngubane"s voice in "Thembi"s AIDS Diary," which was broadcast in English in 2006 on National Public Radio in the U.S., and then in the U.K., Australia, Canada and South Africa (Miller, Wall Street Journal, 6/13).
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Low Blood Glucose Levels Do Not Explain Excess Deaths In Accord Trial
Low blood glucose levels do not explain the excess deaths seen in the intensive control group of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial, according to a report presented here today at the American Diabetes Association"s 69th Scientific Sessions.
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Penn Medicine Honored For Its Historic Role In The History Of Microbiology

The University of Pennsylvania was honored by The American Society for Microbiology last Friday with a plaque dedication ceremony celebrating the designation of its third Milestones in Microbiology site. Formerly known as the Laboratory of Hygiene, the current Vagelos Laboratories resides on the University of Pennsylvania campus. Honorary speakers included Arthur H. Rubenstein, MBBCh, Dean, University of Pennsylvania School of Medicine; Alison O"Brien, PhD, President, American Society for Microbiology; and William B. Whitman, PhD, Trustee and Director of the Editorial Offices, Bergey"s Manual Trust. The Institute of Hygiene opened at the University of Pennsylvania on February 2, 1892 and the name quickly changed to the Laboratory of Hygiene. The building was the first of its kind to be built specifically as a bacteriology laboratory. The new laboratory held the University of Pennsylvania"s first formal courses in bacteriology. Student"s studying medical, dental, veterinary, engineering, and natural science learned about public health and bacteriology within the new walls of the laboratory. Well-known bacteriologist Alexander C. Abbott, one of the founders of the American Society for Microbiology started his profession in the Laboratory. "The University of Pennsylvania is honored to be recognized as a pioneer in the field of bacteriology," said Arthur H. Rubenstein, MBBCh. "We are so proud to keep that tradition alive with our work and research done within our laboratories." The original Laboratory of Hygiene is now the Roy and Diana Vagelos Laboratories located at 3340 Smith Walk on campus. The 102,000 square feet building is used for research in bioengineering, chemistry, chemical engineering, Marc Kaplan University of Pennsylvania School of Medicine


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