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BioElectronics Prepares For General Surgical Recovery FDA 510(k) Premarketing Application Submission
BioElectronics Corp. (PINKSHEETS: BIEL), the maker of inexpensive, disposable drug-free anti-inflammatory devices, announced the Company is currently preparing an application for 510(k) premarket notification for submission to the Food and Drug Administration (FDA) for general surgical recovery. The filing will request an indication for the adjunct of use in palliative treatment of postoperative edema and pain in superficial soft tissue.
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Fruitfly Model Of A Neuropathic Disease Demonstrates Novel Role For Proteins In The Family Of ATyr Pharma's Product Class
Research published in the June 26, 2009 edition of Proceedings of National Academy of Sciences provides further evidence for novel roles of tRNA synthetases in disease, validating the therapeutic potential for aTyr Pharma"s new class of naturally occurring protein agents. The aminoacyl tRNA synthetases are universal and essential components of protein synthesis machinery found in all organisms, but human synthetases have naturally occurring resected variants with potent cell signaling activities that are vital to normal functioning of humans. aTyr Pharma"s proprietary product generating engine consists of these resected proteins (resectins) of human aminoacyl tRNA synthetases with cell signaling activities distinct from the protein synthesis activities. In this recently published study, a model of a human neuropathy was created in the fruit fly (Drosophila) by introducing mutations in the tyrosyl-tRNA synthetase which correspond to disease associated mutations in humans. These dominant mutations do not cause a loss in the protein synthesis activity, indicating that the neuropathy arises from distinct activities of this tRNA synthetase. This work provides further proof of noncanonical roles for tRNA synthetases in human disease.
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FDA Clears Hologic R2(TM) DigitalNow(TM) HD Software Application
Hologic, Inc. (Hologic or the Company) (Nasdaq: HOLX), a leading developer, manufacturer and supplier of premium diagnostics, medical imaging systems and surgical products dedicated to serving the healthcare needs of women, announced that it has received Food and Drug Administration (FDA) clearance for its R2(TM) DigitalNow(TM) HD software application.
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Questioning The Use Of Muscle Rubs

There is not enough evidence to support using gels and creams containing rubefacients for chronic and acute pain, according to a systematic review by Cochrane Researchers. Rubefacients cause irritation and reddening of the skin, due to increased blood flow. The review focused on formulations containing salicylates, which are widely prescribed or sold over the counter as topical treatments for sports injuries and muscle pain. "At present, due to a lack of high quality evidence, we can"t say exactly how effective rubefacients are for acute injuries and there are certainly other more effective treatments which could be prescribed for use in chronic conditions like osteoarthritis," says lead researcher Andrew Moore, of the Nuffield Department of Anaesthetics at the University of Oxford in the UK. There are over a million prescriptions each year for rubefacient gels and creams such as Movelat. As with Movelat, the rubefacient compounds in many of these products are salicylates, which, while they are related to aspirin, may not work in the same way, especially when applied to the skin. They are referred to as "counter-irritants" because it is thought that they offset localised pain through local skin irritation. The review analysed data from 16 trials for acute and chronic pain, which together included 1,276 people. Only salicylates were studied and trials were generally small. Results from four studies showed topical salicylates performed better than placebos against acute pain, but excluding lower quality studies meant the results were not statistically significant. When used for chronic conditions, salicylates performed better than placebos. However, only one in six patients with chronic pain benefited substantially from using the muscle rubs compared to one in three using non-steroidal anti-inflammatory drugs. "Larger and higher quality controlled trials of topical rubefacients are needed to establish whether these treatments really work. We also need more studies on other rubefacients as we were only able to assess the effectiveness of the salicylate formulations in this review," says Moore. "But it is important to remember that not all analgesic gels or creams are the same, and for others there is very good evidence of effectiveness. Those will be dealt with in other reviews presently being finalised." Jennifer Beal Wiley-Blackwell


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