Cardiovascular
The number of people killed by individuals suffering from mental illness in England and Wales increased between 1997 and 2005, figures show. The rise occurred in people who were not under mental health care and was not found in mental health patients.
A recently released AIDS Vaccine Advocacy Coalition report says that although there has been a renewed focus on discovery, innovation and basic science in vaccine research, action is needed to ensure that research funding continues during the economic downturn, VOA News reports. AVAC executive director Mitchell Warren said the report is "about putting all the pieces together ... not just the search for an AIDS vaccine, but in fact the entire HIV prevention response." He added, "[T]he good news is we have some new pieces of the puzzle, and we"re expecting additional new pieces of understanding through research this year." Warren said that AVAC believes HIV/AIDS vaccine research is in "one of the most exciting times," with "new energy, new commitment to unlocking some of the basic scientific roadblocks that have impeded our ability to find a vaccine." For example, a study released earlier this week examined efforts to produce a vaccine through genetic transfer. Regarding the study, Warren said, "It doesn"t mean we have an AIDS vaccine, but it means we have an entirely new approach to trying to deliver protection." Warren said that the field of HIV/AIDS vaccine research has shown a renewed commitment since Merck canceled its vaccine trial in 2007. According to Warren, the new AVAC report examines knowledge gained from the Merck study, which has provided "an unimaginable amount of information." Meanwhile, the effect of the economic crisis on research funding is concerning, Warren said, adding, "I believe that every dollar spent is going to be held up to a greater scrutiny as budgets tighten and as funders have to re-examine their priorities." According to Warren, without renewed funding commitments, "we will not only incur a much greater public health catastrophe, but I would argue that the economic catastrophes to come, if we don"t respond aggressively to HIV, will actually have repercussions that will ... make the economic crisis pale in comparison" (DeCapua, VOA News, 5/18).
"No matter what form of health care reform emerges from the current debates and discussion," Congress should include a "provision to the legislation to permanently exclude abortion from taxpayer-funded health care or health insurance," Family Research Council President Tony Perkins writes in a Politico opinion piece. Although some argue that the government "cannot or should not restrict benefits when it purchases insurance, the same way it does when reimbursing directly for medical procedures," that argument "already failed when it came up in the 1990s in the context of Medicaid managed care plans," Perkins writes, adding that the Hyde Amendment was "revised to cover them, as well." There also are arguments in Congress that "if people can opt for private health insurance that funds abortion and receive a tax break for their purchase of such insurance, then poor people dependent on direct government payments for their health insurance cannot be denied similar coverage," according to Perkins. However, "this presumes that there is no difference between what people may do with their own money and what they may do with the taxpayers" money," Perkins writes, adding that such an argument "makes sense only if we assume it"s all the government"s money in the end" (Perkins, Politico, 7/28).
The Washington Post tells the story of Danny Watt, who drowned in April 2008 after a lifelong struggle with mental health. Watt had a dual diagnosis: a serious mental illness along with abuse of drugs or alcohol.
Researchers may be able to predict future severe cardiac events in patients with known, stable coronary artery disease (CAD) using coronary calcium scoring, according to a study published in the online edition of Radiology.
Uganda"s Health Ministry announced Monday it has ordered investigations into whether the deaths of 17 patients living with HIV in Northern Uganda were caused by their inability to get antiretroviral (ARV) drugs, the AP/mlive.com reports. According to Zainab Akol, manager of the ministry"s HIV/AIDS control program, the ministry is exploring "whether apart from the lack of ARVs, another disease like malaria or any epidemic could have contributed to the deaths," according to the news service.
Illinois health officials contend that images seen in the media, social influences, and a lack of "frank" discussion on STDs in schools, among other issues, might be contributing to increases in STD rates across the state, the State Journal-Register reports. "According to recently released data, new cases of chlamydia in Illinois reached an all-time high statewide in 2008 - 59,169 - while the number of gonorrhea cases outside Chicago has been rising in recent years and totaled 10,165 in 2008," the Journal-Register reports. In addition, about 35,000 state residents have HIV/AIDS, the article states. Charlie Rabins, chief of the STD program at the Illinois Department of Public Health, said a bill (SB 212) currently awaiting Gov. Pat Quinn"s (D) approval might help reduce STD rates. The bill "would allow what is called "expedited partner therapy," in which medical professionals who treat patients for gonorrhea or chlamydia can give those patients single-dose antibiotics to pass on to sexual partners without first examining the partners," according to the Journal-Register (Olsen, 7/27).
A new test developed by Edmonton-based Innovotech Inc. (TSX VENTURE:IOT) will now allow doctors to more accurately identify the right antibiotics required to treat serious, chronic infections that are biofilm based. With more than 80 per cent of infections in the developed world caused by biofilms, the potential for this new breakthrough test, called bioFILM PATM, is of immense significance to the medical community.
The HealthGrades Fourth Annual Bariatric Surgery Trends in American Hospitals Study released today identifies 88 hospitals as "best" performers (five-star rated), with mortality rates, complication rates and patient lengths of stay that are dramatically lower than poorly rated hospitals.
Elron Electronic Industries Ltd. (NASDAQ & TASE: ELRN) announced, that further to it previous announcement on July 28, 2009, Medingo Ltd., a group company held 92% by Elron and its subsidiary, RDC - Rafael Development Corporation Ltd., has received formal clearance from the Food and Drug Administration ("FDA"), to market its Solo™ MicroPump Insulin Delivery System in the United States.
Biotech firm Replikins Ltd. released its analysis of the June and July genomic data that predicts the rates of infectivity and lethality of the H1N1 (Swine Flu) virus. The quantitative analysis shows continued elevated levels in the Replikin Counts* of both Infectivity and Lethality genes, which indicate that the end of the current outbreak is not yet in sight.
Corner shops nationwide will get help from Change4Life to sell fruit and veg - this will mean more people will get their 5 a day and shops will see an increase in profits, Secretary of State for Health Andy Burnham said today.
Concerns are being raised by a growing number of British academics that bureaucratic overload is stifling their ability to undertake clinical research, compromising the future of this activity in the UK, and ultimately doing patients a disservice. The issues are discussed in a Special Report in the August edition of The Lancet Oncology, written by freelance journalist Adrian Burton.
Underscoring the need for meaningful health system reform for America"s patients and physicians, the American Medical Association (AMA) is running an ad emphasizing common ground on health reform to remember what"s at stake - access to care for millions. The AMA ad runs nationally today in the Chicago Tribune, New York Times, and the Wall Street Journal. Online advertising will run in various medical trade publications.
QuatRx Pharmaceuticals Company, a privately-held biopharmaceutical company, announced positive top-line efficacy results from the first of two patient cohorts in its second pivotal Phase 3 trial of the investigational compound, Ophena(TM) (ospemifene tablets), for the treatment of postmenopausal vulvovaginal atrophy (VVA). The Company has also successfully completed two long term safety extension studies from its first pivotal Phase 3 studies. QuatRx intends to use these results in support of a New Drug Application (NDA) with the U.S. Food and Drug Administration (FDA) in early 2010 seeking approval for Ophena(TM), a new SERM (selective estrogen receptor modulator) for the treatment of the symptoms of vulvovaginal atrophy. Ophena(TM) is the only non-estrogen therapy currently in late-stage development for the treatment of vaginal symptoms associated with menopause.
The American Academy of Dermatology (Academy) commends the International Agency for Research on Cancer (IARC) for its re-categorization of indoor tanning devices as carcinogenic to humans. This classification places indoor tanning in the highest cancer risk category afforded by this international agency, which is a division of the World Health Organization (WHO).
Doctors are objecting to one possible provision of a reform bill - favored by the White House and Blue Dogs - that would give an independent commission more power over Medicare payments.
The insurance industry opposes a long-term care proposal called the CLASS Act, currently included in two major health care reform measures.
"As Congress struggles with a massive health care overhaul, several lobbying powerhouses - including the pharmaceutical industry and the nation"s largest advocacy group for retirees - are locked in a contentious fight over the future of biotechnology drugs," USA Today reports in a front page package. "Both sides have spent heavily to sway lawmakers in the debate over how long to keep the expensive drugs exempt from generic competition." The pharmaceutical industry is fighting for 12 years of exclusivity, while President Barack Obama is "pushing for seven years of exclusivity as he looks to trim costs to help pay for his health care plan. ... The pharmaceutical industry counters that a longer period of exclusivity is needed to recover its investments in "biologic drugs," which are made from living organisms and used to treat cancer, multiple sclerosis and other serious diseases."
Lawmakers push bill to fight Medicare fraud as part of health reform legislation.
"Secretary of Health and Human Services Kathleen Sebelius announced Tuesday that $200 million will be available for grants, loans, loan repayments and scholarships for the training of some 8,000 health professionals by the end of fiscal 2010," Congressional Quarterly reports. The money will "provide targeted investments in primary care, nursing, faculty development, and equipment purchases that will shore up the workforce as we prepare for reform," HHS Secretary Kathleen Sebelius said" (7/28).
Massachusetts lawmakers will vote today to provide $40 million to restore health care coverage for legal immigrants.
Senator John Kerry (D-Mass.), chairman of the Senate Foreign Relations Committee, and ranking member, Senator Richard Lugar (R-Ind.), on Tuesday "introduced a bill to overhaul the U.S. system for providing global development aid," the Boston Globe reports (Smith, 7/29). The legislation was also introduced by Senators Robert Menendez (D-NJ) and Bob Corker (R-Tenn.), according to a release from Menendez"s office (7/28).
"Three internationally known organizations based in St. Louis - the Donald Danforth Plant Science Center, the Washington University School of Medicine and St. Louis Children"s Hospital" - have entered into a partnership, known as the Global Harvest Alliance (GHA), which aims to "create inexpensive, nutritionally complete food to help the world"s hungry and undernourished," the AP/Google.com reports. Alliance researchers will focus on several of the most successful approaches used to combat malnutrition and attempt to further enrich foods already used to fight it. "In addition, the alliance aims to help testing and distribution of crops genetically modified to boost nutritional content. They hope to provide the crops cheaply to farmers to produce more nutritious foods," writes the AP/Google.com (Taylor, 7/29).
The Pittsburgh Post-Gazette profiled the Girlfriends Project, a domestic violence and HIV/AIDS education program implemented by the Pittsburgh AIDS Task Force that targets at-risk black women in three Allegheny County, Pa., cities. Blacks "comprise just 7 percent of the total population in southwestern Pennsylvania but 41 percent of those living with HIV/AIDS, according to Allegheny County Health Department statistics provided by the task force," the Post-Gazette reports. "The Girlfriends Project was designed for Braddock, Clairton and Duquesne "because we knew nobody was doing outreach there," project coordinator, Lisa Dukes, said. As part of the project, Dukes hosts Tupperware party-style gatherings in homes of residents where she provides HIV testing and education, sexual health information, safe sex products and cash gift cards. The project is an outgrowth of the CDC"s prevention program Sisters Informing Sisters About Topics on AIDS, or SISTA, and has been so successful that CDC "has asked the task force to introduce it at the CDC"s 2009 National HIV Prevention Conference in Atlanta Aug. 23," the article states (Smith, 7/29).
Adults who use less salt in their diet can experience a slight reduction in their blood pressure in the medium term. However, whether in the long term this can also reduce the risk of late complications in people with sustained high blood pressure, otherwise known as essential hypertension, and whether in the long term their anti-hypertensive medication can be reduced remains unresolved. This is the conclusion of the Institute for Quality and Efficiency in Health Care (IQWiG) in its final report published in the form of a rapid report on 20 July 2009.
Men who have a regular, ongoing relationship with a health care provider are more likely to receive prostate cancer screening and less likely to be diagnosed with advanced prostate cancer, regardless of their race, according to a University of North Carolina study published in the current issue of the journal Cancer.
Elsevier announced that the Journal of Foot & Ankle Surgery (JFAS), the Official Journal of the American College of Foot and Ankle Surgeons (http://www.acfas.org), has been accepted for coverage by multiple Thomson Reuters abstracting and indexing services, including Journal Citation Reports®.
A novel anticancer agent, consisting of a monoclonal antibody linked to a chemotherapy drug, showed substantial antitumor activity in ovarian cancer cell lines and in mice, according to a study published online July 29 in the Journal of the National Cancer Institute.
The Council of the Royal Pharmaceutical Society of Great Britain has announced a fee
The American Lung Association will tell the Environmental Protection Agency (EPA) at a public hearing today to adopt even stronger, health-based national air quality standards for nitrogen dioxide (NO2) than what the agency proposed. Lung Association leadership and healthy air advocates will call for tighter standards at the hearing that begins at 9:00 AM at the EPA Potomac Yard Conference Center located at 1 Potomac Yard, 2777 South Crystal Drive in Arlington, Va. Mary Partridge, American Lung Association National Board Chair, is scheduled to speak at 10:15 AM. The hearing will conclude at 9:00 PM.
CircuLite®, Inc. announced that it has been awarded a Fast-Track Phase I-II Small Business Innovation Research (SBIR) grant from the National Institutes of Health (NIH) to fund the development of a pediatric circulatory assist device based upon CircuLite"s Synergy Pocket Micro-pump. CircuLite, who will collaborate with the University of Maryland School of Medicine on the grant, has received funding from the National Heart, Lung, and Blood Institute at NIH to support the first phase of the grant. The total potential award for Phase I and Phase II could reach up to $3.7 million. Synergy is a micro-blood pump, the size of a AA battery, that can be implanted superficially in a "pacemaker-like" pocket. Synergy is the first and smallest device designed for partial circulatory support (up to 3L/min) and long-term use in adult patients with Class IIIb and early Class IV heart failure. Synergy is currently in a CE Mark clinical trial at multiple centers in Europe.
Helicobacter pylori, nonsteroidal anti-inflammatory drug use and smoking are the most important risk factors for peptic ulcer. Alcohol intake may also play a role in the development of gastric ulcers. Psychological stress may also have an impact on the onset and course of ulcer disease. However, very little is known as to whether childhood adversities involving financial problems, conflicts in the family, problems with alcohol, and matters of personal security are associated with peptic ulcer.
There are at least 100 ways to say, "It hurts!" And that is the problem.
A new study published in a leading medical journal today shows that in Western Cambodia, the parasites that cause malaria have developed
Psychotherapists who treat mothers suffering from postpartum depression and other mood disorders with their infants have developed a proven process that contributes to a greater positive experience with immediate insights for the mothers to develop healthy connections between their maternal experiences and their infants" behaviors.
Schering-Plough Corporation (NYSE: SGP) announced that the U.S. Food and Drug Administration (FDA) Psychopharmacologic Drugs Advisory Committee voted unanimously in favor of SAPHRIS(R) (asenapine) sublingual tablets as effective and safe for the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults and in favor of use in acute treatment of schizophrenia in adults. If approved by FDA, SAPHRIS would be the first psychotropic drug to be approved initially for both of these indications.
Doing something unusual, like knocking on wood or patting yourself on the head, while taking a daily dose of medicine may be an effective strategy to help seniors remember whether they"ve already taken their daily medications, suggests new research from Washington University in St. Louis.
Oregon Health & Science University has been named a Circle of Life Award winner for its innovative program that improves the care of patients near the end of life or with life-threatening conditions.
A new education programme has been developed to provide enhanced training in genetic technologies and clinical applications for healthcare scientists working in laboratory genetics, Health Minister Ann Keen announced.
A new study investigated the effectiveness of S-adenosylmethionine (SAMe) in the prevention and treatment of hepatocellular carcinoma (HCC) or primary liver cancer. SAMe, a widely available nutritional supplement, with little known side effects, was found to be effective in preventing the formation of HCC in rats. However, high enough levels of SAMe were not attainable to successfully treat established HCC. The findings are available in the August issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases.
House Democrats on Wednesday made a deal with fiscally conservative Blue Dog Democrats on a health reform bill that "would reduce the overall cost of the package and ensure more funding for rural hospitals, concessions that could allow the Energy and Commerce Committee to finish its consideration of the legislation," The Washington Post reports. The deal will be considered on the House floor no earlier than September, according to several lawmakers. House lawmakers plan to conclude their markup of the legislation in the Energy Committee Thursday.
Pharmaceutical companies, hospitals, advocacy groups and others with a stake in health reform continue to lobby in hopes of winning concessions in the overhaul, or at least surviving the changes unscathed. "One of the groups key to working any deal is the pharmaceutical industry, which has been quite active behind the scenes," National Public Radio reports. NPR interviewed former congressman Billy Tauzin, who is president of PhRMA, the drug industry"s lobbying group. Tauzin said he couldn"t predict whether health reform, which his group supports, would make the industry wealthier, but added, "we"ll do okay" (7/30).
The U.S. Food and Drug Administration has approved Colcrys to treat acute flairs in patients with gout, a recurrent and painful form of arthritis, and patients with familial Mediterranean fever (FMF), an inherited inflammatory disorder. The medication"s active ingredient is colchicine, a complex compound derived from the dried seeds of a plant known as the autumn crocus or meadow saffron (Colchicum autumnale).
An annual report by the Health Council of East Central Florida released on Wednesday said that nearly 800 new cases of HIV were reported in Central Florida in 2008 and blacks and Hispanics remain disproportionately affected, the Orlando Sentinel reports. The report was presented to the Ryan White Planning Council, according to the Sentinel. The report said that there are now more than 4,000 people living with HIV in the area, and another 4,400 living with AIDS. In addition, a majority of the new cases of HIV were among blacks and Hispanics, according to the report (Maza, 7/29). In an interview with the Sentinel, Debbie Tucci, the Orange County Health Department"s HIV/AIDS program coordinator, discussed the findings. She said, "HIV/AIDS is not in the forefront the way it used to be. We"ve been talking about this for a long time, and people just don"t think it"s going to happen to them." She added, "The disease doesn"t care what your race or ethnicity is. Now we target minorities more, and what"s happened is that they"re getting tested more. Prevention strategies are absolutely working. There"s always room for improvement, but we"ve come a long way - especially among minorities" (Maza, 7/30).
Scientists at Washington University School of Medicine in St. Louis have identified a substance in the liver that helps process fat and glucose. That substance is a component of the common food additive lecithin, and researchers speculate it may one day be possible to use lecithin products to control blood lipids and reduce risk for diabetes, hypertension or cardiovascular disease using treatments delivered in food rather than medication.
Older breast cancer patients are not receiving a full range of treatment options, according to a report published in the British Journal of Cancer.
Continuing to help ensure the identity, purity and quality of heparin, the U.S. Pharmacopeial (USP) Convention has revised written and physical standards for the widely used blood thinner. In February, USP released updated heparin standards at the request of the Food and Drug Administration (FDA) in response to the 2008 public health crisis in which more than 200 people died as a result of heparin adulterated for economic gain. A second phase of revisions is reflected in the newly posted standards. These developments and new information about heparin were discussed by scientists and regulators at the third International Heparin Workshop held at USP headquarters in Rockville, Maryland, July 27.
From time to time, Headway is made aware of worthy causes it believes it should provide its support to.
Family service agencies are missing huge opportunities to help children by focusing only on mothers and ignoring fathers, according to a groundbreaking study by some of the nation"s top family and child development researchers.
Recent questions about the death of Michael Jackson have focused media attention on the commonly used intravenous anesthetic propofol. In the April 2009 issue of Anesthesia & Analgesia, the leading clinical journal for anesthesiologists, Robert R. Kirby, James M. Colaw and Michael M. Douglas reported on a 24-year-old woman whose 2005 death was attributed to propofol toxicity.
King Pharmaceuticals, Inc. (NYSE: KG) announced additional information regarding the resubmission plan for the REMOXY® New Drug Application (NDA). The Company is not required by the Food and Drug Administration (FDA) to conduct clinical trials in order to provide additional safety or efficacy data in patients with moderate to severe chronic pain. However, as part of the resubmission plan, and in order to strengthen the NDA, King plans to conduct a likeability study and a pharmacokinetic trial in volunteers. The Company continues to anticipate the resubmission could occur mid-year 2010.
The Senate Appropriations Committee on Thursday approved its fiscal year 2010 spending bill (HR 3293) for health, education and labor programs, CQ Today reports. The bill does not include funding for abstinence-only sex education, instead providing $104.5 million for a comprehensive "Teen Pregnancy Prevention" program. The recently passed House version of the bill takes a similar approach, according to CQ Today.The committee voted 29-1 to approve the $730 billion bill, with abstinence-only advocate Sen. Sam Brownback (R-Kan.) being the sole opponent (Wolfe, CQ Today, 7/30).In related news, Sen. Arlen Specter (D-Pa.) in the FY 2010 spending bill did not request funding for abstinence-only sex education programs in his home state, despite routinely requesting such funds as a Republican, CQ Politics reports.When he was a Republican, Specter sponsored 22 earmarks totaling $550,000 for abstinence-only programs in the FY 2009 version of the bill. Specter"s aides said that he wanted to focus earmark requests on hospitals and universities in the FY 2010 version of the bill. However, the "likely" explanation for the absence of abstinence-only earmark requests is the senator"s 2009 switch to the Democratic Party, which often advocates for comprehensive sex education programs as a way to reduce teen pregnancy, CQ Politics reports (Clarke, CQ Politics, 7/29).
Kaiser Health News reports that an agreement by House Democrats with fiscally conservative Blue Dog Democrats has a cadre of detractors, including "state officials worried about increased Medicaid costs and liberal lawmakers upset about a proposed reduction in subsidies for low-income families to buy insurance."
Small synthetic fragments of genetic material called small interfering RNA (siRNA) can block production of abnormal proteins; however, these exciting new drug candidates can also induce a strong immune response, causing toxic side effects. Understanding how siRNA stimulates this undesirable immune activity, how to test for it, and how to design siRNA drugs to avoid it are critical topics explored in a timely review article published online ahead of print in Oligonucleotides, a peer-reviewed journal published by Mary Ann Liebert, Inc.
International patients spending $3 billion a year on care in the United States are helping fund a gap for hospitals waiting with bated breath to see how health care reform will affect them, Marketplace reports.
Global Health Aid Should Take An "Integrated Approach"
Gastroesophageal reflux diseases , or GERD, affects about 10 million people in the United States, yet the cause and an unexpected increase in its prevalence over the last three decades remains unexplainable. Now, researchers have discovered that GERD is associated with global alteration of the microbiome in the esophagus. The findings, reported in the August 1, 2009 issue of Gastroenterology, may provide for the foundation for further study of the condition as a microecological disease with new treatment possibilities.
To meet the needs of its diverse clinician and patient constituency, EmblemHealth announced on Friday publication of what is believed to be the first comprehensive guide to help physicians and medical professionals address the needs of patients whose health care decisions are influenced by their religious and cultural beliefs. The Medical Manual for Religio-Cultural Competency is sponsored by EmblemHealth and created by the Tanenbaum Center For Interreligious Understanding, a global leader in training health care providers to offer religiously and culturally competent care for patients of all ages and backgrounds.
Physicians should recommend low to moderate levels of exercise to their pregnant patients, even if they have not exercised prior to pregnancy, states a report published in the August 2009 issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS). According to this review article, exercise can strengthen and improve overall musculoskeletal and physiologic health as well as pregnancy related symptoms. Exercise such as aerobics, impact and nonimpact activities, resistance training and swimming:
Oxygen levels while flying are substantially less than at ground level. Current guidelines for in-flight oxygen levels are sufficient to support the needs of passengers with non-obstructed lung disease. According to two articles published in the Wiley-Blackwell journal, Respirology, commercial air travel appears to be safe for patients with lung disease as the current policies for the in-flight oxygen levels and availability of supplemental oxygen can adequately accommodate passenger"s needs.
"A week-old agreement among House Democrats to smooth out disparities in the way Medicare reimburses rural and urban health providers is in danger of crumbling, as disputes erupted Friday over what actually was agreed to," The Wall Street Journal reports. "Some lawmakers from states with high health-care costs are also pressing House Democratic leaders for changes to the deal to ensure that their doctors and hospitals don"t see too big of a bite. ò€¦ Lawmakers from populous areas are questioning whether the deal on geographic disparities should be altered to allow more time for Medicare changes to take effect, since there is no longer the urgency of putting those changes into effect before the public option is rolled out. Another issue is for how long a period of time after changes go into effect urban hospitals should be "held harmless," meaning they won"t see their Medicare reimbursements cut" (Vaughan, 8/2).
Study 1 Twins born as a result of assisted reproductive technology (ART) are more likely to be admitted to neonatal intensive care and to be hospitalised in their first three years of life than spontaneously conceived twins, according to new research published online in Human Reproduction [1].
A new study published in the August issue of The Journal of Nuclear Medicine shows that positron emission tomography (PET) is an important tool for depicting the extent of neuroblastoma in some patients, particularly for those in the early stages of the disease. Neuroblastoma accounts for six to ten percent of all childhood cancers in the United States and 15 percent of cancer deaths in children. Accurately identifying where in the body the disease is located and whether it is spreading is critical for choosing appropriate types of treatment, which can include surgery, chemotherapy, radiation and-in the most advanced cases-a combination of all of these treatments along with bone marrow transplant or investigational therapies.
Researchers at the University of Minnesota and National Institutes of Health have identified a new function for the protein missing in people with the most common and ultimately lethal form of childhood muscular dystrophy.
Brain scientists and cardiac surgeons at Johns Hopkins have evidence from 227 heart bypass surgery patients that long-term memory losses and cognitive problems they experience are due to the underlying coronary artery disease itself and not ill after-effects from having used a heart-lung machine.
Boston Scientific Corporation (NYSE: BSX) welcomed the launch of a new website, http://www.syntaxscore.com, dedicated to the understanding and use of the SYNTAX Score™, a novel angiographic tool used to measure the complexity of coronary artery disease. The Company made the announcement at the annual EuroPCR Scientific Program in Barcelona.
Whether it"s highlighted in major news headlines about Argentinean affairs and Ponzi schemes, or in personal battles with obesity and drug addiction, individuals regularly succumb to greed, lust and self-destructive behaviors. New research from the Kellogg School of Management examines why this is the case, and demonstrates that individuals believe they have more restraint than they actually possess - ultimately leading to poor decision-making.
Like the sensitive seismographs that can pick up tremors of impending earthquakes long before they strike, a similar invention from Tel Aviv University researchers may change the face of molecular biology.
Flasks, beakers and hot plates may soon be a thing of the past in chemistry labs. Instead of handling a few experiments on a bench top, scientists may simply pop a microchip into a computer and instantly run thousands of chemical reactions, with results - literally shrinking the lab down to the size of a thumbnail.
Interventional radiology procedures are on the rise in developing countries and there is a significant need for optimization of these procedures to ensure patient safety. Many facilities in these countries lack the concept of patient dose estimation and dose management, putting patients at a higher risk of developing complications due to overexposure from radiation during interventional procedures, according to a study performed by the International Atomic Energy Agency in Vienna, Austria.
There is mounting evidence that omega-3 fatty acids from fish or fish oil supplements not only help prevent cardiovascular diseases in healthy individuals, but also reduce the incidence of cardiac events and mortality in patients with existing heart disease. A new study, published in the August 11, 2009, issue of the Journal of the American College of Cardiology, extensively reviews data from a broad range of studies in tens of thousands of patients and sets forth suggested daily targets for omega-3 consumption.
Drug companies may exploit new rules to promote their products to the public but present it as mere provision of information, according to an editorial published this week in the Drug and Therapeutics Bulletin (DTB).
Nurses who make home visits to children with asthma can help prevent half of those children from having to receive more serious treatment for their condition, suggests research published ahead of print in the Archives of Disease in Childhood.
Moffitt Cancer Center and Frantz BioMarkers, LLC have signed a license agreement on phospholipid biomarkers of ovarian cancer. Frantz BioMarkers, which has been granted exclusive worldwide rights to Moffitt"s interests in the biomarkers, will pay initiation, developmental milestone and license maintenance fees, and royalties on sales. Moffitt and Frantz BioMarkers will collaborate on ovarian cancer biomarker research, combining use of these licensed markers with lipid markers developed independently by Frantz BioMarkers.
Cephalon, Inc. (Nasdaq: CEPH) announced yesterday that the Journal of Clinical Oncology has published data from a pivotal phase 3 study demonstrating that TREANDA® (bendamustine HCl) for Injection improved clinical outcomes when compared to chlorambucil in patients with chronic lymphocytic leukemia (CLL). Results of this study were the basis of the March 2008 U.S. Food and Drug Administration (FDA) approval of TREANDA for CLL, the first agent approved by the FDA for this disease since 2001. According to the American Cancer Society, there will be more than 15,000 new cases of CLL diagnosed in 2009 alone. The study results were published online today and will also appear in the print edition later this year.
As the field of stem cell based therapies has progressed, there have been numerous questions about the exact way one of the most promising lines of adult stem cells works to repair damaged heart muscle. Although cells obtained from adult bone marrow are proving to be useful to treat heart disease, there has been a major controversy over whether they are true stem cells capable of forming new heart muscle.
Two common anti-influenza drugs - Relenza and Tamiflu - appear equally effective at preventing common flu symptoms when given before infection, say researchers from the Stanford University School of Medicine. However, data is lacking on the effectiveness and safety of the two drugs in vulnerable groups such as the very young and people with compromised immune systems.
Angiotech Pharmaceuticals, Inc. (NASDAQ: ANPI, TSX: ANP) announced the launch of a series of new, proprietary Quill(TM) SRS product codes specifically designed for laparoscopic, or minimally invasive, gynecology procedures, including hysterectomies and myomectomies. In 2008, there were approximately 750,000 hysterectomies performed in the United States of which approximately 130,000 were performed laparoscopically. In addition, there were approximately 72,000 myomectomies performed in the United States to remove uterine fibroid tumors. Management estimates 6-8% annual growth in laparoscopically assisted hysterectomies through 2014.
Covidien (NYSE: COV), a leading global provider of healthcare products, has announced a key milestone in the continued growth and use of the OxiNet™ III remote respiratory monitoring system in U.S. hospitals. With the recent system installation at the Mayo Clinic campus in Jacksonville, FL, the Nellcor™ OxiNet III system currently monitors 10,000 beds and is integrated into more than 450 U.S. hospitals, including the Mayo Clinic campus in Rochester, MN, M.D. Anderson Cancer Center (Houston, TX), St. Anthony Central Hospital (Denver, CO) and Sumner Regional Medical Center (Gallatin, TN). The OxiNet III remote monitoring system enhances the safety of patients throughout the hospital, enabling continuous monitoring of patients" oxygen saturation levels via the trusted Nellcor OxiMax™ product platform, even when the clinician is not at the bedside.
Boston"s health agency on Tuesday is scheduled to launch a safer-sex campaign that reaches out to teenagers through Web sites such as Facebook and YouTube, the Boston Globe reports. The campaign was created in response to rising rates of sexually transmitted infections among young people in the city, according to the Globe. The $100,000 campaign originally was intended to address communicable diseases in general. However, experts noticed the increase in STI cases among teenagers and decided to spend all the funding on the campaign targeting STIs.The increase in chlamydia cases in particular demonstrates the "scope of the challenge," as 1,383 Boston youths between ages 15 and 19 were diagnosed with the STI in 2007, a 70% increase since 1999, the Globe reports. The overall rate of chlamydia in Boston is more than twice the national average, and chlamydia and gonorrhea are more common among adolescents than any other age group in Boston. According to the Globe, a city study released in early 2009 found that 56% of Boston public high school students have had sex, and 24% of the sexually active students said they have had more than six partners.For the campaign, "teenagers will do much of the talking" in a video that offers information on STIs, the Globe reports. The video will air on cable channels that are popular with teenagers, such as MTV, FX and BET. It shows teenagers in a classroom receiving information on safer sex, including details about condoms and STI screening. The video does not discuss sexual abstinence.The campaign also includes advertisements on mass transit and the radio, as well as a team of teenagers that will travel around Boston performing street theater addressing the risks associated with STIs. Through the social networking Web site Facebook, teenagers can post questions anonymously regarding sexual health that will be answered by a disease specialist. Videos related to the campaign also will be posted on YouTube.Margaux Joffe, multimedia coordinator at the Public Health Commission, said teenagers "told us, "We don"t want some 40-year-old woman telling us about sex and STIs."" Joffe added that it "makes sense" because a teenager "may not trust the advice of an adult as much as you would someone in your peer group." Mark Schuster, the chief of general pediatrics at Children"s Hospital Boston who was not involved in the design of the campaign, said that using a "multilevel approach" to address the issue is a "great strategy." He added that young people "can be interested and learn from" a sex education curriculum in school, but "they need it in other settings too."Specialists speculate that the rise in STIs may reflect teenagers" casual attitudes about sex and parents" shifting attention to other children"s health concerns, the Globe reports. Experts also have said that the increase in STIs could reflect increased screening efforts by physicians, who have been "pressed for many years to screen much more carefully kids at younger and younger ages," Stephen Boswell, president of Fenway Health, said. The Globe reports that teenagers do not view HIV/AIDS in the same way previous generations have because of advancements in treatment, so preventing the virus "no longer seems quite as important." Experts are concerned that the spread of other STIs could be a forewarning of a rise in HIV/AIDS cases among teenagers. Anita Barry, a top disease specialist at BPHC, said the gonorrhea and chlamydia cases are "our future HIV cases unless we intervene" (Smith, Boston Globe, 8/4).
Planned Parenthood of Alaska and an Anchorage high school teacher filed a lawsuit in Anchorage Superior Court on Friday to block a voter initiative that would make it illegal for minors younger than age 18 to obtain abortion services without parental notification, the Anchorage Daily News reports. Supporters of the initiative, which was certified on July 2, must gather nearly 33,000 signatures in order for it to be put on the ballot in August 2010.The lawsuit claims that the initiative should not have been certified because of what the newspaper termed "legal technicalities" and because the ballot description of its impact is misleading. According to legal documents filed by Planned Parenthood and teacher Susan Wingrove, the language of the initiative indicates that minor changes would be made to an existing law "rather than making clear that the initiative is abolishing rights currently afforded to the citizens of Alaska who are minors." They also claim that the initiative does not make it clear that violations of the law would be a felony and that it would be the responsibility of the physician to inform parents.Previous attempts to enact parental notification and consent laws have failed in Alaska. The Alaska Parental Consent Act, which was approved in 1997, said that parental notification or approval from a judge was necessary before a minor could obtain an abortion. Legal challenges prevented the act from going into effect, and the Alaska Supreme Court in 2007 ruled that the law was unconstitutional. In addition, a bill that would have required girls younger than age 17 to notify a parent failed to make it through the state Legislature this year.Former Lt. Gov. Loren Leman (R), a supporter of the new initiative, called Planned Parenthood of Alaska and the teacher "desperate," adding that they "would deny the people of Alaska the opportunity to participate in the initiative process" (Holland, Anchorage Daily News, 7/31).
As legislators seek to sell what has so far been a largely Washington insider effort, many Americans are confused about what health care reform actually entails.
A report from President Obama"s Council of Economic Advisers finds that "health care reform would be good for small businesses because it would enable them to obtain better insurance coverage for less money," The Denver Business Journal writes. "Small businesses pay up to 18 percent more than large businesses do for the same coverage because of high broker fees, administrative costs and adverse selection, according to the CEA"s report." Christina Romer, chair of the CEA, "said the health care reform bills moving through Congress are specifically designed to address the burden the current health care system places on small businesses. The legislation would create insurance exchanges, where individuals and small businesses could "choose among a multitude of plans that would provide better coverage at lower costs than they could find in the current small group market," the report said." But, The Journal notes: "Many small business groups also doubt that health insurance would be cheaper under the House bills or the Senate HELP Committee bill. Including a government-run plan in the insurance exchange would undermine private insurers, ultimately driving premiums higher, they contend. Not all small businesses would be able to access the exchange. Plus, the bills call for the federal government to establish minimum coverage levels for insurance plans, which could be pricier than what small businesses now provide. (Hoover, 8/3).
In an essay in The Washington Post, an infectious disease specialist writes that "the unspoken truth among doctors is that we objectively or subjectively ration care, and often don"t tell patients or their families." Organs, for example, "are a precious commodity, their donation strictly regulated by national guidelines. ò€¦ Because donors are scarce, it seems appropriate to ration their organs on the basis of need and other ethical and medical considerations." Medical care is also rationed through long wait times to see physicians (ranging from 11 to 50 days in major cities, according to a 2009 survey by Merritt Hawkins & Associates) or shortages of beds in a hospital.
"Louisiana will start paying less money Tuesday to many private health care providers for taking care of Medicaid patients, a move the state health department estimates will save $86 million this year," The Associated Press/The Advocate reports. Adults in the program may also have to pay a small co-pay if they visit emergency rooms for non-emergency care. "The cuts come as the health department shrinks its spending to $7.9 billion in the new fiscal year that began July 1, down $240 million from last year. Nearly all the cuts will be levied on the Medicaid program for the poor, elderly and disabled. But Jerry Phillips, state Medicaid director, said the department believes it can cover nearly two-thirds of that gap through efficiencies and the continuation of other cuts made during the last budget year."
Kaiser A small, rural hospital in Missouri is "rolling the dice" on electronic medical records, its CEO tells the Associated Press. The 47-bed hospitals borrowed nearly $1 million to implement an electronic records system, and that"s on top of a $370,000 operating deficit and staff layoffs. The executives are banking on a government bailout in the form of a "$3 million windfall" of stimulus-funded incentives for hospitals to switch to electronic record-keeping.
Liverpool School of Tropical Medicine (LSTM) is leading a project to provide technical assistance to the Libyan government to finalise the development of a national HIV strategy and programme of support. The project is supported by a 1 million euro grant from the Delegation of the European Commission to Libya.
More than 35 million Americans suffer from bladder control problems at some time in their lives. Those suffering from uncontrollable bladder may experience unexpected urine leakage, frequent bathroom use, or have the feeling of not being able to completely empty the bladder. Many people experience a combination of these symptoms. Although it is more common in older adults, and more likely to occur in women than men, it can affect anyone.
Specific changes in brain pathways may counteract genetic mutations for the movement disorder dystonia, according to new research in the August 5 issue of The Journal of Neuroscience. Few people who inherit dystonia genes display symptoms - namely sustained muscle contractions and involuntary gestures - and the study provides a possible explanation. This result could lead to new treatments for the estimated 500,000 North Americans diagnosed with dystonia.
Geckos are very adept at climbing through difficult terrain using an intricate adhesive system. Until now it has not been known when and how they switch on their unique system of traction.
Cooling unconscious cardiac arrest survivors can increase survival and has a cost effectiveness comparable to other widely accepted treatments in modern health care, researchers report in Circulation: Cardiovascular Quality and Outcomes.
The Mount Sinai Medical Center has a new re center for prostate cancer treatment. Led by David B. Samadi, M.D., Chief of the Division of Robotics and Minimally Invasive Surgery in the Department of Urology, the new state-of-the-art facility at 625 Madison Avenue in New York City specializes in pre- and post-surgery care for patients who undergo a robotic prostatectomy at Mount Sinai"s main campus. It also provides expertise in the treatment of other urologic cancers, including bladder and kidney. A multilingual staff offers assistance with patient travel arrangements, accommodations, and translation services when required.
In its fight against an intruding virus, an enzyme in our immune system may sense certain types of viral RNA pairs, according to scientists.
Although lead content in paint has been restricted in the United States since 1978, University of Cincinnati (UC) environmental health researchers say in major countries from three continents there is still widespread failure to acknowledge its danger and companies continue to sell consumer paints that contain dangerous levels of lead.
Due to workforce shortages, doctors are struggling to maintain their involvement in teaching and in research activities, according to an article published in the Medical Journal of Australia. Further, the demands for doctors to teach medical students and doctors-in-training are increasing, with even more medical students now enrolled.
A study just published on bmj.com reports that the risk of heart attack is multiplied by two for men who have angina. Also their risk of suffering a heart disease-related death is three times higher than for women with the same condition.
A gut hormone first described in 1928 plays an unanticipated and important role in the remote control of blood sugar production in the liver, according to a report in the August 6th Cell Metabolism, a Cell Press publication. What"s more, the researchers show that rats fed a high-fat diet for a few days become resistant to the glucose-lowering hormone known as cholecystokinin (CCK).
As we all know from experience, people eat not only because they are hungry, but also because the food just simply tastes too good to pass up. Now, a new study in the August 6th Cell Metabolism, a Cell Press publication, helps to explain how leptin, a hormone produced by fat tissue, influences that motivation to eat.
HIV and sexual health charity Terrence Higgins Trust (THT) is joining forces with other local HIV organisations to remind visitors to Birmingham Pride (23 - 24 May) not to put their sexual health at risk by getting carried away with the party mood.
"Attempts to set billions aside for infrastructure projects like bike paths face an uphill battle on Capitol Hill," The Chicago Tribune reports, adding "GOP legislators see no health savings in parks and similar projects," while advocates say preventive efforts will bring down costs. "A draft Senate bill would provide up to $10 billion annually for a "prevention and public health investment fund" -- a portion of which could be used for projects such as bike paths, sidewalks, farmers markets and other community interventions meant to curb chronic and costly conditions like obesity."
It is important to understand what biological mechanisms contribute to an individual"s capacity to be resilient under conditions of extreme stress, such as those regularly experienced by soldiers, police, and firefighters. Dr. Charles A. Morgan III and his colleagues from Yale University and the VA National Center for PTSD have worked closely with collaborators at the Special Forces Underwater Warfare Operations Center to study special operations soldiers enrolled in the military Combat Diver Qualification Course (CDQC).
Timberline Knolls, one of the country"s leaders in the treatment of eating disorders, is recognizing well-known tennis star, Monica Seles, for disclosing her history with an eating disorder in her new book Get a Grip. Ms. Seles" display of courage and candor has the potential to help many others who have similar struggles, especially young female athletes.
Can-Fite BioPharma (TASE:CFBI), a biotechnology company traded on the Tel Aviv Stock Exchange, an Israeli Biopharmaceutical company, announced today that its 80-patient Phase II clinical study using CF101 to treat patients with moderate to severe Dry Eye Syndrome had successfully met the primary efficacy endpoint. Patients in this masked study were randomly assigned to either 1 mg of CF101 or matching placebo; drug was taken orally as a monotherapy for 12 weeks. The 12 week duration is one that Can-Fite has used in other trials of CF101 as an anti-inflammatory agent, and is similarly a common one for Phase II trials of Keratoconjunctivitis Sicca. The patient group receiving CF101 demonstrated statistically significant improvement in superficial punctate keratitis, relative to the placebo group, as measured by fluorescein staining. This sensitive and prevalent measure of corneal disease was prospectively defined as a primary study endpoint, thus demonstrating the ability of orally administered CF101 to exert beneficial effects on ocular surface inflammation. An improvement in additional study parameters was also observed. CF101 was safe and well tolerated during the study period.
Siemens Corporate Research (SCR), Inc. announced that it developed the RAPID2 system to speed the biomarker discovery process for the development of rapid diagnostic tests. This system marries the power of information technology with today"s improved genomic sequencing to quickly identify genomic signatures unique to the set of organisms to be detected. These signatures are the foundation for a new generation of molecular diagnostic tests for the rapid detection of healthcare-associated infections such as the potentially deadly Methicillin-Resistant Staphylococcus Aureus (MRSA).